Autoantibody-mediated disorders of the central and peripheral nervous system: Overview Infection

Yury Zharikov, Anna Shitova, Polina Melnikova, Ilya Voloshin, Maria Orliuk, Anna Olsufieva, Andr´e Pontes-Silva, Tatiana Zharikova
Journal of Neuroimmunology, 2025, https://www.jni-journal.com/article/S0165-5728(25)00097-9/abstract
HIV-associated neurocognitive disorders are a common manifestation of HIV infection, affecting more than half of HIV-infected individuals, including those receiving targeted antiviral therapy. A common feature of the course of HIV infection during therapy is large-scale immune responses in the brain. Several pathways are involved in the neuropathogenesis of HIV infection: Cellular entry, inflammatory processes in microglia, activation of astroglia, myeloid cells, and damage to brain vessels leading to neurocirculatory disorders. Data on vascular diseases that influence the development of neurocognitive impairment in HIV-positive patients will also be examined, as well as better intervention strategies for complex neurocognitive disorders and neurodegenerative processes in HIV infection.